Mammalian cell culture is a core expertise area for Shannon ABC. Cell culture is the process by which cells can be grown under controlled conditions and can be an excellent way to determine mode of action and efficacy for a wide range of compounds.
Cell culture analysis provides an effective platform to assess the biological efficacy of potential ingredients and compounds in a time-efficient manner. Shannon ABC have two independent state of the art cell culture suites within our facilities.
Cell culture is a strategic starting point for testing ingredients in a relevant cell line to assess their potential as a novel ingredient or formulation. This provides a valuable screening tool to enable companies to make informed decisions regarding the performance and impact of their ingredients or products. This allows companies to decide whether a particular ingredient may be suitable for further research and ultimately be brought to market. Shannon ABC have capabilities within cell culture to examine many areas, such as:
- Cell proliferation
- Pro/Anti-inflammatory activity
- Antioxidant activity
- Collagen production
- UV protection
Cell lines which we have previously worked with include:
- Caco-2 (human intestinal epithelial cell line)
- L929 (murine fibroblast)
- HDFa (adult human dermal fibroblasts)
- Keratinocyte human cell line
- THP1 (human macrophages)
- J774 (mouse macrophages)
- HSkMC (human skeletal muscle cells)
- C2C12 (mouse muscle cells)
- hFOB (primary human fetal osteoblasts)
Scientists at Shannon ABC also have experience with 3D cell models, such as in vitro reconstructed human epidermis, which allows direct application of skincare products.
Shannon ABC have a team of experienced cell culture scientists and would be happy to discuss potential cell culture-based models to fit your R&D requirements. Please click here to contact us.